The article focuses on the founding narratives of Kulturwissenschaft/en in Germany (studies of culture) that have been addressed in the last decades. According to these narratives, Kulturwissenschaft/en are either described as the result of a fundamental crisis of the humanities or as the result of a radical transformation of the lifeworld since the 19th century. These narratives, however, have not lead to an epistemological foundation of German Kulturwissenschaft/en. Against this background, the article outlines in which ways Kulturwissenschaft as a discipline can be understood as an academic reflexion based on experiences of otherness and difference. Therefore, it will be argued that an epistemology of Kulturwissenschaft may provide a broader framework reflecting the complex and conflictual relation of academic research and culture as well as media as essential conditions of cultural knowledge.